Indolactam-V Is Involved in the CH/x Interaction with Pro-I I of the PKCδ C1B Domain: Application for the Structural Optimization of the PKCδ Ligand.
The article presents information on protein kinase C (PKC) isozymes are the main receptors of tumor promoters such as phorbol esters and teleocidins. After hydrolysis of the acetal, the asymmetric Strecker reaction was applied to the resulting aldehyde to give an (R)-amino nitrile diastereoselectiv...
| Published in: | Journal of the American Chemical Society Vol. 127; no. 16; pp. 5746 - 5748 |
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| Main Authors: | , , , , |
| Format: | Article |
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American Chemical Society
4/27/2005
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=16924210&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 16924210 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 4/27/2005 vid: 127 iid: 16 pid: 997 pub: American Chemical Society artinfo: ui: 16924210 10.1021/ja050447d ppf: 5746 ppct: 2 formats: tig: atl: Indolactam-V Is Involved in the CH/x Interaction with Pro-I I of the PKCδ C1B Domain: Application for the Structural Optimization of the PKCδ Ligand. aug: au: Nakagawa, Yu Irie, Kazuhiro Yanagita, Ryo C. Ohigashi, Hajime Tsuda, Ken-ichiro affil: Kyoto University. NEC Corporation. su: Organic compounds Protein kinases Isoenzymes Phorbol esters Hydrolysis Hydrogenation sug: subj: Organic compounds Protein kinases Isoenzymes Phorbol esters Hydrolysis Hydrogenation ab: The article presents information on protein kinase C (PKC) isozymes are the main receptors of tumor promoters such as phorbol esters and teleocidins. After hydrolysis of the acetal, the asymmetric Strecker reaction was applied to the resulting aldehyde to give an (R)-amino nitrile diastereoselectively. The nitrile group was converted to the methyl ester, which was then reduced with lithium borohydride. Reduction of the nitro group and removal of the phenylethanol group of 4 were achieved by hydrogenation. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2005 holdings: @attributes: islocal: N |
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