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Indolactam-V Is Involved in the CH/x Interaction with Pro-I I of the PKCδ C1B Domain: Application for the Structural Optimization of the PKCδ Ligand.

The article presents information on protein kinase C (PKC) isozymes are the main receptors of tumor promoters such as phorbol esters and teleocidins. After hydrolysis of the acetal, the asymmetric Strecker reaction was applied to the resulting aldehyde to give an (R)-amino nitrile diastereoselectiv...

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Published in:Journal of the American Chemical Society Vol. 127; no. 16; pp. 5746 - 5748
Main Authors: Nakagawa, Yu, Irie, Kazuhiro, Yanagita, Ryo C., Ohigashi, Hajime, Tsuda, Ken-ichiro
Format: Article
Published: American Chemical Society 4/27/2005
Subjects:
Organic compounds
Protein kinases
Isoenzymes
Phorbol esters
Hydrolysis
Hydrogenation
Online Access:View this record in EBSCOhost