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Indolactam-V Is Involved in the CH/x Interaction with Pro-I I of the PKCδ C1B Domain: Application for the Structural Optimization of the PKCδ Ligand.

The article presents information on protein kinase C (PKC) isozymes are the main receptors of tumor promoters such as phorbol esters and teleocidins. After hydrolysis of the acetal, the asymmetric Strecker reaction was applied to the resulting aldehyde to give an (R)-amino nitrile diastereoselectiv...

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Publicado en:Journal of the American Chemical Society Vol. 127; no. 16; pp. 5746 - 5748
Autores principales: Nakagawa, Yu, Irie, Kazuhiro, Yanagita, Ryo C., Ohigashi, Hajime, Tsuda, Ken-ichiro
Formato: Artículo
Publicado: American Chemical Society 4/27/2005
Materias:
Organic compounds
Protein kinases
Isoenzymes
Phorbol esters
Hydrolysis
Hydrogenation
Acceso en línea:Ver este registro en EBSCOhost
Sumario:The article presents information on protein kinase C (PKC) isozymes are the main receptors of tumor promoters such as phorbol esters and teleocidins. After hydrolysis of the acetal, the asymmetric Strecker reaction was applied to the resulting aldehyde to give an (R)-amino nitrile diastereoselectively. The nitrile group was converted to the methyl ester, which was then reduced with lithium borohydride. Reduction of the nitro group and removal of the phenylethanol group of 4 were achieved by hydrogenation.